Orlistat is used to treat obesity and help in weight loss. Orlistat is to be used along with a low-calorie diet and regular physical exercise. Obesity is a common condition associated with excessive body fat, which in turn increases the risk of other health problems such as diabetes, high blood pressure, certain cancers, and heart disease. Intake of more calories than you burn by exercise or daily activities results in obesity.
Orlistat contains Orlistat, which works in the small intestine and stomach and prevents the action of enzymes that break down fat, which is absorbed by the body. Orlistat decreases the absorption of fat from the food you eat. Thus, fat passes through the gut and is excreted in the faeces, which makes the body unable to use fat as a source of energy or convert it into fat tissue. Thereby, Orlistat helps in weight loss.
Take Orlistat as prescribed by your doctor. You are advised to take Orlistat for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience soft stools, sudden bowel motions, flatulence (gas) with or without oily spotting, oily or fatty stools, stomach pain, stool incontinence (involuntary leakage of stools), and runny or liquid stools. Most of these side effects of Orlistat do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.
If you are allergic to Orlistat or any other medicines, please tell your doctor. Avoid taking Orlistat if you are pregnant or planning for pregnancy, as it may cause fetal harm. It is not known whether Orlistat is excreted in human milk. Therefore, please consult a doctor if you are a breastfeeding woman. Orlistat is not recommended for children below 18 years of age, as the safety and effectiveness were not established. You are advised to take a multivitamin containing fat-soluble vitamins such as A, D, E, and K at bedtime as Orlistat may reduce the absorption of certain vitamins in the body.
Contains Orlistat - Uninterrupted diet?Theual diet is a multivitamin containing fat-soluble vitamins such as A, D, E, and K which helps in reducing the absorption of certain vitamins in the body. The multivitamin contains fat-soluble vitamins such as A, D, E, and K which help in reducing the absorption of fat-soluble vitamins in the body. The recommended dose of Orlistat is one multivitamin taken 30 minutes to 1 hour before a meal. The maximum daily dose of Orlistat is one multivitamin taken once a day.
Orlistat is not recommended for use in patients with kidney disease. Therefore, please consult your doctor for the full details of your medical condition.
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Uninterrupted diets are not recommended for patients with kidney disease. You are advised to take a multivitamin containing fat-soluble vitamins such as A, D, E, and K as Orlistat may reduce the absorption of certain vitamins in the body. The recommended dose of Orlistat is one multivitamin taken once a day.Excessive use of alcohol?Avoid excessive alcohol consumption while taking Orlistat as it may increase the risk of side effects such as stomach pain, bowel movements, and leakage of stools. If you experience leakage of stools, inform your doctor right away.
possible adverse effects of OrlistatOrlistat works by binding to a certain type of fat-soluble protein in the small intestine. A enzyme called lipase breaks down fat in the intestine. Orlistat works by inhibiting the action of lipase, the enzyme which breaks down fat in the stomach. Lipase is located in the small intestine and in the stomach that carries out bodily functions. Orlistat reduces the absorption of fat-soluble vitamins such as A, D, E, and K in the body. Thus, fat-soluble vitamins pass through the intestinal tract and are excreted in the faeces. Without a thorough diet, a diet that is rich in good in calories may not be suitable for you. Hence, a reduced intake of calories may be more beneficial for you. Therefore, you are advised to take Orlistat for as long as your doctor has prescribed it for you based on your medical condition.
Orlistat is an effective and safe medication in the management of obesity and its associated conditions, but its efficacy has been understudied. In this study, the efficacy of orlistat was evaluated in obese patients with type 2 diabetes mellitus. The primary efficacy endpoint was weight changes after three weeks of treatment, and the secondary endpoints included change in serum glucose concentrations, changes in the total body weight and in body weight after 1 month of treatment. Safety and tolerability were evaluated in the safety population. In the orlistat-treated patients, the incidence of gastrointestinal adverse events was similar to placebo. No serious adverse events were reported, and all patients were well-controlled on the drug. However, most of the patients were lost to follow-up at least once in at least two weeks. Orlistat is considered a safe and effective treatment in the management of obesity and its associated conditions.
Orlistat is a semisynthetic and non-selective fat binding agent, which inhibits lipase activity by binding to the active site in lipoprotein lipase. The lipoprotein lipase enzyme is involved in fat digestion and absorption, which is believed to be the key factor in obesity. Orlistat has demonstrated significant weight loss and reduction in obesity, and is also a potent inhibitor of the inflammatory pathway that may contribute to the development of obesity. The antiobesity effects of orlistat are mediated through its ability to reduce the synthesis of free fatty acids from triglycerides. The clinical trials for orlistat were conducted over three years and included the primary efficacy endpoints [see.
The data on the effects of orlistat in the orlistat-treated patients were consistent with a dose-dependent relationship with weight changes. Orlistat was found to be well-tolerated, with a median of 3.9% weight loss from the first week of treatment [4.8% weight loss after 3 weeks of treatment], and no serious adverse events (all non-life-threatening) were reported. This is in contrast with a study of orlistat in obese patients with type 2 diabetes mellitus, which found that the rate of weight loss was similar to that seen in non-obese patients [].
Orlistat was evaluated in the primary efficacy endpoints, as well as the secondary endpoints, in an open-label, randomized, single-center, parallel-group, randomized, double-blind, placebo-controlled trial. The primary efficacy endpoints included changes in body weight and total body weight over 3 months, as well as the change in total body weight over 2 weeks in the treatment group [.
The study was stopped after the primary endpoints were completed, and all patients had a reduction in their BMI by more than 15%. In addition, the primary efficacy endpoints included changes in body weight and total body weight over 3 months, as well as change in body weight over 2 weeks in the orlistat-treated patients [.
The study was stopped at 12 weeks. Although, the primary efficacy endpoints did not reach statistical significance, the results showed that there was no significant difference between orlistat and placebo in the change in total body weight over 2 weeks. At 2 weeks, orlistat and placebo showed a statistically significant decrease in total body weight compared to placebo (p < 0.05). Orlistat and placebo also showed a statistically significant decrease in total body weight compared to placebo (p < 0.05). At 12 weeks, the difference in total body weight in the orlistat and placebo groups was not significantly different from the difference in weight change between the orlistat and placebo groups.
All patients were clinically stable on all trial endpoints during the study. The primary efficacy endpoints were the change in BMI over 1 month, which was assessed by the change in the body weight and total body weight, as well as the change in BMI over 2 weeks. In the orlistat-treated patients, the incidence of adverse events was similar to placebo, and there were no serious adverse events reported in all patients. All patients were well-controlled on the trial endpoints.
Orlistat was evaluated in a randomized, open-label, two-period, double-blind, parallel-group, placebo-controlled, double-dose, dose-response, dose-titration study.
Healthy weight loss
Top tips for healthy weight loss:
To help you find out if you have a healthy body weight, measure your and waist circumference To lose weight, the energy you take in from food must be less than the energy you use – eat less, move more!
Set yourself realistic goals to achieve a healthy weight. Even small amounts of weight loss can have significant health benefits and can help to set you on a path to a healthier future. Guidelines recommend that you should try to lose weight gradually, about 1-2 lbs (approximately 0.5-1.0 kg) a week
Weight loss can reduce your risk of: heart disease, stroke, type 2 diabetes and some cancers.
It can also reduce the risk of:
High blood pressure Angina (heart condition causing chest pain) High blood cholesterol levels Lower back and joint pain Fertility problems BMI and waist circumference
For most adults:
A BMI between 18.5 and 25 is defined as healthy. A BMI of over 25 is defined as overweight. A BMI of over 30 is defined as obese.
Waist-circumferences for which there is an increased risk and high risk of obesity-related health problems:
Increased risk High risk Men ≥94 cm (37 in) ≥102 cm (40 in) Women ≥80 cm (31.5 in) ≥88 cm (34.5 in)
Sensible weight loss should be seen as an overall lifestyle change which involves eating a healthy balanced diet and doing plenty of physical activity.
Guidelines recommend that you should try to lose weight gradually, about 1-2 lbs (approximately 0.5-1.0 kg) a week. This way, the weight is more likely to stay off. This rate of weight loss is based on using up 600 kcal per day more than you take in. On average, this means consuming no more than 1,400 kcal a day if you are a women, and no more than 1,900 kcal a day if you are a man. The amount of weight you lose will depend on how much weight you need to lose and how active you are.
Further information can be found on the manufacturers
Side Effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Orlistat.
The majority of unwanted effects related to the use of Orlistat result from its local action in your digestive system. These symptoms are generally mild, occur at the beginning of treatment and are particularly experienced after meals containing high levels of fat. Normally, these symptoms disappear if you continue treatment and keep to your recommended diet.
Very common (may affect more than 1 in 10 people):
headache abdominal pain/discomfort urgent or increased need to open the bowels flatulence (wind) with or without discharge oily discharge, oily or fatty stools liquid stools low blood sugar levels (experienced by some people with type 2 diabetes) upper respiratory infections flu (influenza)
If you have has any Bought this product
- drink lots of alcohol before you commit to a new behaviour
- commit to a new behavior Read all instructions from executement before you take this medication
- take this medication by mouth with or without food
- take this medication consistently at least two hours after taking orlistat
- if you are a woman, no daily change is needed
- if you are a man, no daily change is needed
- if you are a combination of both these two these two medications can increase the risk of or avoid weight loss
Gastrointestinal careThis medicine is available only by the pharmaceutical companies who made it:
Pharmacological companies: Novartis, Merck, GlaxoSmithKline.
Chemical estate
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Orlistat is a lipase inhibitor. The active ingredient is Orlistat. Orlistat is broken down by the kidney to absorb this unbroken down process. This enzyme converts the small molecule drug …
The enzyme lipase is responsible for breaking down dietary fat into very small components.
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How does the drug interact with Orlistat:Co-administration of Orlistat with Phentermine can increase the risk of seizures.How to manage the interaction:Co-administration of Orlistat with Phentermine can lead to an interaction, it can be taken if prescribed by a doctor. You should avoid the use of Phentermine after the meals if you have anorexia or bulimia. You should also refrain from taking Orlistat with Phentermine if you have a history of liver disease or alcohol abuse. You should consult your doctor if you're taking Phentermine.
Taking Orlistat with Phentermine can increase the risk of seizures.Taking Orlistat with Phentermine after the meals if you've anorexia or bulimia. You should avoid Orlistat after the meals if you have anorexia or bulimia.
Taking Orlistat with Phentermine can lead to an interaction, but you should avoid Orlistat after the meals if you have anorexia or bulimia. You should consult a doctor if you're taking Phentermine.
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